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Clavulanic acid : ウィキペディア英語版 | Clavulanic acid
Clavulanic acid (rINN) is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. In its most common form, the potassium salt potassium clavulanate is combined with: * amoxicillin (co-amoxiclav, trade names Augmentin, Tyclav (Beximco), Synulox (HREF="http://www.kotoba.ne.jp/word/11/veterinary" TITLE="veterinary">veterinary ), and others) or * ticarcillin (co-ticarclav, trade name Timentin). Clavulanic acid is an example of a clavam. ==Sources== The name is derived from the ''Streptomyces clavuligerus'', which produces clavulanic acid. Clavulanic acid is biosynthetically generated from the amino acid arginine and the sugar glyceraldehyde 3-phosphate.
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